Gary Taylor-Fletcher's first-half double helped Blackpool secure all three points at Middlesbrough.
Soon after Boro's Dave Kitson went close with a header, Barry Bannan passed to Taylor-Fletcher who battled through to side-foot home the opener.
Bannan and Taylor-Fletcher linked well again for the striker to double the lead after curling in a cracker.
Injured Boro captain Gary O'Neil was carried off late on to leave Charlie Adam to hammer in a fine third.
Middlesbrough boss Gordon Strachan (on his team's poor home form):
"It's not just the players - I need to go back, and the coaching staff need to go back and see how we approached this game.
"It is becoming a trend, doing well away from home and not so well at home.
"And I find it surprising because the supporters are absolutely fantastic. They're very, very patient."
Blackpool manager Ian Holloway:
"Don't start talking about promotion. We need to stay up, that's what my chairman wants me to do.
"We've got a group of people who are enjoying what they are doing, trying to learn their jobs.
"I'm trying to tell them when they are in certain areas, what to do and why to do it. They're taking it on board."
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