Ian Holloway's Blackpool recorded their fourth consecutive home win to leave his former side Plymouth struggling at the foot of the table.
Marcel Seip, on loan from Plymouth, opened the scoring with a glancing header from a Charlie Adam free-kick as Blackpool dominated the first half.
The visitors improved after the break before David Vaughan made it 2-0 with a fine shot from the corner of the box.
Plymouth never gave up hope but rarely threatened to get on the score sheet.
The two sides' contrasting fortunes were shown by their approach to the game in the early stages.
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Ipswich 1 - 1 Swansea
Under-fire Ipswich boss Roy Keane is still searching for his first win of the season after being held by Swansea.
Craig Beattie put the Swans ahead with his first goal for the club after seven minutes, smashing the ball past debutant keeper Asmir Begovic.
But that lead was cancelled out eight minutes later when Pablo Counago side-footed home from close range.
Ipswich looked threatening from set pieces but could not find a way through as Swansea held firm.
It means Keane's side have failed to win any of their opening 12 Championship games and remain rooted to the bottom of the table.
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