SATURDAY
Portsmouth v Everton, 12.45pm
Portsmouth must do without winger Jermaine Pennant who has torn a calf muscle, with Nadir Belhadj and John Utaka likely to step in.
Everton will be without defender Joseph Yobo after he picked up a hamstring injury in training.
Tim Cahill should return after a calf injury.
Portsmouth squad: James, Johnson, Campbell, Distin, Hreidarsson, Davis, Mullins, Kranjcar, Nugent, Crouch, Basinas, Belhadj, Utaka, Kaboul, Kanu, Traore, Hughes, Wilson, Begovic.
Everton squad: Howard, Neville, Jagielka, Lescott, Baines, Pienaar, Osman, Cahill, Fellaini, Saha, Jo, Rodwell, Baxter, Nash, Castillo, Jacobsen, Gosling, Wallace, Van der Meyde.
Blackburn v West Ham, 3pm
Blackburn captain Ryan Nelsen (thigh) and fellow defender Gael Givet (knee) will undergo fitness tests.
Striker Roque Santa Cruz is out with a knee tendon issue, midfielder Vince Grella remains out with a groin injury.
Stephen Warnock has been cleared to play after shaking off a toe injury.
West Ham will make a late check on Matthew Upson (calf) and Savio Nsereko.
Kieron Dyer and Diego Tristan are fit and in contention for a place, while Jack Collison (knee) and Carlton Cole (suspended) are still out.
Blackburn squad: Robinson, Bunn, Ooijer, Khizanishvili, Nelsen, Samba, Simpson, Warnock, Givet, Olsson, Villanueva, Tugay, Andrews, Diouf, Treacy, Mokoena, Dunn, McCarthy, Roberts, Pedersen.
West Ham squad: Green, Neill, Ilunga, Parker, Savio, Kovac, Upson, Noble, Tomkins, Di Michele, Sears, Lastuvka, Lopez, Boa Morte, Spector, Tristan, Payne, Stanislas, Dyer.
Fulham v Man Utd, 3pm
Clint Dempsey is a doubt for Fulham after food poisoning while Aaron Hughes ruled out with a rib problem.
Veteran defender Gary Neville is back in the squad after a groin strain. Darren Fletcher (virus) is included while Jonny Evans is likely to replace the suspended Nemanja Vidic.
Fulham squad: Schwarzer, Pantsil, Stoor, Hangeland, Konchesky, Baird, Davies, Etuhu, Dacourt, Murphy, Gera, Dempsey, Johnson, Zamora, Zuberbuhler, Kallio, Nevland, Kamara, Gray, Barnes.
Man Utd squad: Van der Sar, Foster, Kuszczak, O'Shea, Ferdinand, Evans, Neville, Evra, Eckersley, Fabio, Ronaldo, Nani, Fletcher, Gibson, Carrick, Anderson, Giggs, Scholes, Park, Berbatov, Rooney, Tevez, Welbeck.
Stoke v Middlesbrough, 3pm
Stoke expect to have Matthew Etherington back from an ankle injury.
Striker Ricardo Fuller is still troubled by a shoulder injury but is in the squad.
Middlesbrough will be without suspended midfielder Matthew Bates as well as Didier Digard (knee and thigh) and Chris Riggott (knee).
Skipper Emanuel Pogatetz will undergo a late fitness test on a knee injury, while Jeremie Aliadiere is also a doubt with a knock.
Stoke squad: Sorensen, Wilkinson, Abdoulaye Faye, Shawcross, Higginbotham, Lawrence, Whelan, Diao, Delap, Etherington, Beattie, Sidibe, Fuller, Simonsen, Pugh, Amdy Faye, Sonko.
Middlesbrough squad: Jones, Turnbull, Hoyte, McMahon, Taylor, Pogatetz, Wheater, Huth, Arca, O'Neil, Downing, Aliadiere, Walker, A. Johnson, Tuncay, Emnes, King, Alves, Franks.
Tottenham v Chelsea, 3pm
Tottenham striker Jermain Defoe is out as he is still recovering from his foot injury.
Alan Hutton also has been rehabilitating from a foot injury but Ledley King's knee should have recovered from Sunday's win at Aston Villa.
Chelsea are without midfielder Deco who has a hamstring injury.
Midfielder Joe Cole and defender Paulo Ferreira remain sidelined with knee ligament damage but strikers Nicolas Anelka (toe) and Didier Drogba (knee) are both fit.
Tottenham squad: Gomes, Cudicini, Corluka, Chimbonda, Bale, Dawson, Woodgate, King, Assou-Ekotto, Zokora, Bentley, Huddlestone, Jenas, Lennon, Palacios, Modric, O'Hara, Pavlyuchenko, Bent, Keane, Campbell.
Chelsea squad: Cech, Hilario, Taylor, Bosingwa, Mancienne, Alex, Terry, Ivanovic, A Cole, Belletti, Ballack, Obi, Lampard, Essien, Kalou, Malouda, Di Santo, Anelka, Drogba, Quaresma.
West Brom v Bolton, 3pm
Baggies defender Abdoulaye Meite has been ruled out with a hamstring injury.
Fellow centre-back Leon Barnett is facing several weeks on the sidelines with a knee problem.
Bolton midfielder Mark Davies is out with a knee injury while defender Joey O'Brien is struggling with a long-term knee complaint.
West Brom squad: Carson, Zuiverloon, Olsson, Martis, Robinson, Morrison, Dorrans, Koren, Brunt, Greening, Fortune, Teixeira, Simpson, Moore, Kiely, Hoefkens, Cech, Bednar.
Bolton squad: Jaaskelainen, Steinsson, Cahill, Andrew O'Brien, Samuel, Riga, Taylor, McCann, Muamba, Gardner, Kevin Davies, Elmander, Al Habsi, Hunt, Puygrenier, Makukula, Shittu.
Newcastle v Arsenal, 5.30pm
Newcastle will welcome back Kevin Nolan from suspension.
Full-back Habib Beye is also available after damaging ankle ligaments, although midfielder Danny Guthrie (hamstring) is not yet ready to return.
Joey Barton (fractured metatarsal) is targeting the end of next month for his comeback, but Mark Viduka and Ignacio Gonzalez (both Achilles) and Xisco (fractured toe) remain on the sidelines.
Arsenal should have keeper Manuel Almunia available after an ankle problem.
Defender Mikael Silvestre (calf) could also come into contention while Cesc Fabregas (knee) and striker Eduardo (groin) are back in training but are not expected to feature
Emmanuel Adebayor (hamstring) and Tomas Rosicky (hamstring tendon) continue their rehabilitation.
Newcastle squad: Harper, Forster, Krul, S. Taylor, Beye, Bassong, Coloccini, Enrique, Edgar, Cacapa, Butt, Duff, R. Taylor, Gutierrez, Nolan, Lovenkrands, Geremi, Ameobi, Smith, Martins, Owen, Carroll.
Arsenal squad: Almunia, Sagna, Toure, Gallas, Clichy, Nasri, Denilson, Song, Walcott, Arshavin, Van Persie, Fabianski, Djourou, Gibbs, Vela, Bendtner, Eboue, Diaby, Silvestre.
SUNDAY
Wigan v Hull, 1.30pm
Wigan winger Antonio Valencia is a slight doubt with a hamstring problem.
Midfielder Lee Cattermole serves the second game of a four-match suspension.
Hull captain Ian Ashbee has been ruled out but Kevin Kilbane and Dean Marney return.
Centre-backs Michael Turner and Anthony Gardner are rated 50/50, while midfielders Jimmy Bullard and George Boateng (both knee) are long-term absentees.
Wigan squad: Kirkland, Melchiot, Scharner, Bramble, Figueroa, Watson, N'Zogbia, Valencia, Kapo, Zaki, Mido, Pollitt, Edman, Brown, Boyce, Rodallega, Sibierski, De Ridder, Koumas.
Hull squad: Myhill, Ricketts, Turner, Gardner, Dawson, Mendy, Kilbane, Marney, Zayatte, Garcia, Geovanni, Manucho, Cousin, Barmby, Fagan, Folan, Featherstone, Hughes, France, Duke.
Man City v Sunderland, 3pm
Manchester City midfielder Stephen Ireland (ankle) and Wayne Bridge (hamstring) are doubtful.
Vincent Kompany and Craig Bellamy (knee) could be in contention.
Sunderland defenders Anton Ferdinand and Nyron Nosworthy could return after hamstring injuries.
Tal Ben Haim is unavailable, Teemu Tainio has a knee problem while Kieran Richardson completes a two-match ban.
Man City squad: Given, Hart, Schmeichel, Richards, Onuoha, Dunne, Bridge, Garrido, Zabaleta, Wright-Phillips, Elano, Caicedo, Ireland, Fernandes, Vassell, Weiss, Robinho, Evans, Bojinov, Berti, Etuhu, Bellamy.
Sunderland squad: Fulop, Gordon, Bardsley, McCartney, Collins, Ferdinand, McShane, Nosworthy, Davenport, Whitehead, Malbranque, Leadbitter, Edwards, Yorke, Reid, Cisse, Jones, Murphy, Healy.
Liverpool v Aston Villa, 4pm
Liverpool full-back Alvaro Arbeloa is back after a hamstring problem.
Xabi Alonso (ankle) and Yossi Benayoun (hamstring) are back in light training and have a good chance of being involved.
Villa striker John Carew is back to full fitness following a back problem.
Left-back Wilfred Bouma is ready to play a part after eight months out with a dislocated ankle while midfielder Steve Sidwell could also come into the equation.
Liverpool squad: Reina, Arbeloa, Carragher, Hyypia, Skrtel, Dossena, Aurelio, Babel, Benayoun, Mascherano, Riera, Gerrard, Alonso, Torres, Kuyt, Agger, Cavalieri, Lucas, Ngog.
Aston Villa squad: Friedel, Guzan, Reo-Coker, L. Young, Knight, Cuellar, Davies, Shorey, Bouma, Milner, Gardner, Petrov, Barry, Sidwell, Salifou, A. Young, Agbonlahor, Carew, Heskey, Delfouneso, Harewood.
www.thesun.co.uk